The 8 Best Vitamins and Supplements for Stress, According to Dietitians

The best stress-reduction vitamins and supplements promote physical health and promote relaxation. L-theanine, ashwagandha, melatonin, and other supplements are among the best for stress.
Everybody has stressors in their lives, but the most prevalent ones are usually connected to relationships, money, health, and work pressure.

Acute or chronic stress can cause headaches, nausea, anxiety, and irritability or anger.

A healthy diet, regular exercise, and adequate sleep are some of the best ways to better prepare your body to handle stress, but a number of vitamins and supplements can also be helpful.

The top seven vitamins and supplements that could aid in stress management are listed here. Based on recent studies, we explain how each component might aid in stress management.

Best overall

Ritual Stress Relief

The three components of Ritual’s Stress Relief supplement—ashwagandha, L-theanine, and saffron—are well-known for their ability to reduce stress.

80 mg of ashwagandha

Native to India, ashwagandha (Withania somnifera) is an adaptogenic herb that has been utilised in Indian Ayurveda, one of the oldest medical systems in the world.

60 people with mild stress were randomly assigned to receive 240 mg of a standardised ashwagandha extract or a placebo daily for 60 days as part of a 2017 study on the plant’s ability to reduce stress.

Ashwagandha supplementation was linked to a higher decrease in anxiety when compared to the placebo. Additionally, ashwagandha was associated with a 23% decrease in morning cortisol levels, a stress hormone.

200 mg of L-theanine

Tea leaves are the most common source of the amino acid L-theanine.

Its capacity to encourage relaxation and lower stress levels without producing sedative effects has drawn the attention of researchers.

Taking 200 mg of L-theanine daily significantly improved depression symptoms, stress, sleep quality, and cognitive function when compared to a placebo, according to a high-quality study involving 30 participants.

30 adults with moderate stress levels participated in a 2024 study in which they were given 400 mg of L-theanine or a placebo every day for 28 days. L-theanine users demonstrated lower levels of light sleep and larger drops on lab-based stress measures compared to the placebo group.

28 mg of saffron

It is believed that saffron has calming properties. There is some evidence to support the use of saffron in stress and anxiety management.

56 participants in a 2020 study took 30 mg of saffron every day for eight weeks. They self-reported better social relationships and reduced depression. Additionally, one of the indicators of stress resilience improved.

According to a 2022 review, the effects of saffron’s constituent safranal are comparable to those of the common anxiety drug diazepam. Both block specific nervous system signals linked to anxiety by binding to particular gamma-aminobutyric acid (GABA) receptors in the brain.

A 2019 meta-analysis, however, found that while saffron might help manage anxiety, the amount and quality of the available data were insufficient. Additional research is required to validate the impact of saffron on stress.

Ritual vitamins are free of GMOs, vegan-friendly, and third-party tested.

Best with adaptogens

HUM Nutrition Big Chill

The herb rhodiola (Rhodiola rosea) is found in parts of Asia and Russia.

It has long been recognised as an adaptogen, a herb that is believed to boost stress resistance by activating your body’s stress response system.

 

Two of rhodiola’s strong active ingredients, rosavin and salidroside, are associated with its adaptogenic qualities.

Despite the paucity of human research, a 2022 review concluded that rhodiola supplementation may lessen anxiety, depression, and stress and fatigue.

In a similar vein, a 2020 analysis of five studies on rhodiola supplementation and mood disorders discovered evidence that it may alleviate the symptoms of mild anxiety and depression.

HUM Nutrition Big Chill is among the greatest choices if you want to try rhodiola.

Each serving of the supplement contains 500 mg of R. rosea extract, an effective dosage based on clinical research. Additionally, it has undergone third-party testing and is devoid of artificial colouring and sweeteners.

Best with melatonin

Life Extension Melatonin IR/XR

Best with magnesium

SFI Health Magnesium Glycinate Complex

Best with ashwagandha

Klaire Labs Ashwagandha Extract

Best with L-theanine

Pure Encapsulations L-Theanine

How to choose supplements for stress

When looking for supplements to help with stress, bear the following points in mind:

Intended effect: Does stress interfere with your ability to concentrate or sleep? Seek out a product designed to deal with your particular problems. For instance, rhodiola and L-theanine are better choices for concentration and productivity, while melatonin may help with sleep.
Cost: Cost is a crucial factor. Knowing how much you’ll be spending each month is crucial if you plan to take supplements for a long time.

Quality: It’s critical to choose products from reputable brands because the FDA does not regulate supplements in the same manner as it does medications. To guarantee purity and potency, try to find products that have undergone third-party testing.
Expert assistance: It’s a good idea to speak with a healthcare provider before beginning to take supplements. They can assist you in ordering blood work, making product selections, or analysing your diet to determine whether you’re lacking in any vital nutrients that could influence your stress levels.
Drug interactions: It’s crucial to consult a healthcare provider before taking any new supplements if you’re currently taking prescription or over-the-counter medications because certain supplement ingredients may interact with them.